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Observe Carefully (one)pentobarbital will lessen the level or outcome of cannabidiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or impact of darifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the level or effect of sunitinib by affectin